The U.S. health care system still can’t identify medical harm as it occurs. But it’s now possible to develop systems that correct their own deficiencies and make improvements that matter to patients.

Whether endovascular therapy benefits patients with mild acute ischemic stroke from large-vessel occlusion involving the ...

When patients, or the parents of patients, become heavily invested in searching for someone to blame for an illness, it’s useful to ask what the search is doing for them. Its accuracy is rarely ...

In 2015, pivotal randomized, controlled trials established the benefit of endovascular treatment for acute ischemic stroke due to a large-vessel occlusion. 1,2 The trials showed a major clinical ...

Savolitinib is an oral, potent, highly selective MET–tyrosine kinase inhibitor (TKI). Combination therapy with savolitinib and osimertinib, an epidermal growth factor receptor (EGFR)–TKI, has shown ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 10).

Agencies have long relied on civil monetary penalties to address violations of health care and public health regulations. But rules governing federal fines are now in flux.

To improve the quality of observational studies, target trial emulation requires careful specification of design elements, analytic methods for addressing confounding, and reporting of sensitivity ...

A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interle ...

Patients with extensive-stage small-cell lung cancer have poor outcomes, with a median overall survival of approximately 12 to 13 months. Tarlatamab (a bispecific T-cell engager targeting delta-like ...

One afternoon, at the beginning of my first clinical clerkship in internal medicine, my team was called to the intensive care unit. A patient, whom I'll call Mr. Abbott, had just been admitted with ...

U.S. clinicians, health systems, and policymakers should recognize immigration enforcement as a social determinant of health currently implicated in a public health crisis and act accordingly.